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Estimated 24-h profiles of plasma ghrelin, adiponectin, and leptin in lean (a–c) and obese (d–f) subjects. For each group, mean hormone levels are plotted as circles. The semiparametric linear mixed-effects model, across-subject prediction is drawn as a solid line. Dashed lines trace out the prediction's approximate 95% confidence interval. Arrows indicate standardized meals (breakfast, lunch, dinner, and evening snack), and the sleep period is demarcated by a black strip.
