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Twenty-four-hour profiles of rapidly sampled plasma leptin in lean (blue) and obese (red) male subjects. Arrows indicate standardized meals (breakfast, lunch, dinner, and evening snack), and the sleep period is demarcated by a black strip. Blood samples were collected in a general clinical research center after two nights of acclimatization in the research room. Lights were on during 0700–2300 hours and off during 2300–0700 hours, during which time subjects slept.
