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. 2016 Mar 1;7:10634. doi: 10.1038/ncomms10634

Figure 3. β-adrenergic signalling is necessary for stress-induced remodelling of tumour LVD and lymphatic metastasis.

Figure 3

(a) Representative images and quantification of tumour LVD (LYVE-1+, green; nuclear, blue) immunostaining and bioluminescence imaging of vehicle- or propranolol-treated mice with MDA-MB-231 primary tumours 22 days post tumour cell injection (n=5). Scale bar, 200 μm. N.S.=not significant. (b) Representative images and quantification of tumour LVD (LYVE-1+, green; nuclear, blue) immunostaining and bioluminescence imaging of vehicle- or isoproterenol (Iso)-treated mice with MDA-MB-231 primary tumours (n=5). *P<0.05, **P<0.01 and ***P<0.001 by Mann–Whitney U-test or two-way analysis of variance (post hoc Tukey's adjustment).