Figure 3b:
MPO activity and its product decreased with MPO inhibition ex vivo and in vivo. (a) Plot shows that peroxidase activity decreased with MPO inhibition 6 hours after SE (n = 6 per group; P = .02, according to results of the Student t test). (b) Representative SPECT/CT images show that in vivo MPO activity increased after SE and was partially blocked with MPO inhibition. (c) Three-dimensional representations of MPO activity in the entire mouse brains are shown for the same groups as those in in b. (d) Plot shows the quantification of imaging findings (according to the Kruskal-Wallis test, followed by the Dunn multiple-comparisons test). All data in plots are means ± standard errors of measurement.