Table 4.
Linear regression models predicting frailty from relative telomere length (RTL) within tertiles of difference-based methylation age acceleration
| Stratum of age acceleration | Dataset 1 | Dataset 2 | Overall | p a |
|---|---|---|---|---|
| Tertile 1 (below −1.85 years) | 0.132 (−1.253, 1.517) | −0.809 (−3.548, 1.930) | −0.106 (−1.274, 1.063) | 0.86 |
| Tertile 2 (−1.85 to <2.43 years) | −0.982 (−2.635, 0.672) | −0.404 (−2.266, 1.459) | −0.506 (−1.689, 0.678) | 0.40 |
| Tertile 3 (≥2.43 years) | 0.960 (−0.763, 2.682) | −0.135 (−1.881, 1.611) | 0.338 (−0.829, 1.504) | 0.57 |
Shown is the estimated change (95 % confidence interval) of the frailty index (expressed in %) per standard deviation of RTL. All models adjusted for age, sex, leukocyte distribution, and random effects of telomere and methylation array batch
a p values refer to t distribution tests of the estimates obtained by multiple imputation in the overall model