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. Author manuscript; available in PMC: 2017 Jan 12.
Published in final edited form as: Cell Metab. 2015 Dec 8;23(1):63–76. doi: 10.1016/j.cmet.2015.11.002

Figure 6. Low-ΔΨm CD8+ T cells demonstrate increased long-term in vivo persistence and superior anti-tumor activity.

Figure 6

(A–B) Flow cytometric analysis and quantification of persistence of transferred Thy1.1+ CD8+ T cells 300 days after adoptive transfer of 105 high-ΔΨm and low-ΔΨm cells in sub-lethally irradiated mice (mean ± s.e.m. of 4 mice). (C–D) Vitiligo scores and melanophage uveitis scoring in mice that received ΔΨm CD8+ T cell subsets. (E) Adoptive transfer of 106 high-ΔΨm or low-ΔΨm cells and subsequent infection with gp100-vaccinia virus in sub-lethally irradiated mice bearing 10-day established subcutaneous B16 tumors (n=5 mice per group). Data are presented as mean ± SEM and * = P < 0.05; ** = P < 0.01 (two-tailed t test). (E) ** P =0.009 (Wilcoxon rank sum).