FIGURE 9.
Model illustrating different partners and functions of three BRPF proteins. BRPFs recruit and activate lysine acetyltransferases such as MOZ, MORF, and HBO1 to regulate gene expression. All three acetyltransferases are authentic partners of BRPF1, but only HBO1 interacts with BRPF2 and BRPF3 as well. Mouse Brpf1 deficiency results in embryonic lethality at E9.5 (25, 26) and Brpf2 deletion causes lethality at E15.5 (24). By contrast, Brpf3 is non-essential for mouse survival and development (Figs. 4–7), distinguishing mammalian BRPF3 from its paralogs BRPF1 and BRPF2. Thus, despite high sequence homology, these three proteins have distinct functions in vivo.