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. 2015 Nov 28;44(2):538–544. doi: 10.1093/nar/gkv1312

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© The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Models of rRNA silencing after DSBs. (A) DSBs in rDNA silence rRNA transcription locally and induce nucleolar segregation and cap formation in an ATM-dependent manner. In nucleolar caps rDNA associate with NHEJ and HDR factors in a cell cycle independent manner. (B) DSBs in non-nucleolar DNA induce ATM-dependent translocation of NBS1-TCOF1 into nucleoli and global silencing of rRNA transcription.