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. Author manuscript; available in PMC: 2016 Jun 4.
Published in final edited form as: Annu Rev Genomics Hum Genet. 2015 Jun 4;16:55–77. doi: 10.1146/annurev-genom-090413-025437

Figure 2.

Figure 2

Proteins and mechanism responsible for establishing, recognizing, and removing mCH. DNMTs, including DNMT3a, DNMT3b, and DNMT3L, are part of the complex responsible for the establishment and maintenance of mCH. MeCP2 is able to recognize non-CG-methylated regions. A non-CG demethylase has not yet been identified, and it is speculated that passive dilution (resulting from DNA replication and lack of maintenance of mCH) is the mechanism underlying the loss of mCH in dividing cells. Abbreviations: DNMT, DNA methyltransferase; mCH, non-CG methylation; MeCP2, methyl-CpG binding protein 2.