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. 2016 Jan 19;6:19345. doi: 10.1038/srep19345

Figure 2. Density profiles for neurotransmitters with extracellular binding sites.

Figure 2

The density curves indicate that aspartate, glutamate, serine, glycine, GABA, and acetylcholine do not attach to the extracellular leaflet. For serotonin, there exist receptors with membrane-buried binding sites and extracellular binding sites (Table 1), but the NT attached to all membranes. Also shown (on the right, bottom) are the extracellular binding sites of the GluA2 glutamate receptor and the 5HT-3 serotonin receptor (Table S1).