Fig. 4.
Bmpr1a deletion increases the proliferation of Sp7+ preosteoblasts. (A) Representative images for BrdU staining of longitudinal femur sections at P33. (B) Quantification of BrdU-positive cells (%) at the chondro-osseous junction. (C) Representative images for EdU labeling (green) and Sp7 immunostaining (red). Area in red box is shown at higher magnification to the right. Arrows indicate Sp7+ EdU+ cells (yellow). GP, growth plate; M, marrow. (D) Quantification of Sp7+ EdU+ cells among total Sp7+ cells. WT, Bmpr1af/f; MT, Dmp1-Cre; Bmpr1af/f. *P<0.05, n=3.