FIG 1.
Genomic context of the cdaAR genes and the domains of CdaA and CdaR. (A) The diadenylate cyclase CdaA and its potential regulator CdaR are encoded by the bicistronic cdaAR operon (38), which is surrounded by the putative lmo2121 maltose phosphorylase gene and the glmM gene encoding the essential phosphoglucosamine mutase. Arrows and circles illustrate transcription start sites and terminators, respectively (38). (B) CdaA contains three N-terminally located α-helices that form a transmembrane (TM) domain. The TM domain is attached to the diadenylate cyclase (DAC) domain, which is surrounded by two coiled-coil (CC) motifs. CdaR is predicted to contain a signal peptide (SP) and four YbbR domains of unknown function (24, 25, 26).