Figure 3. Three classes from the apo-state ensemble.
(A) The reconstructed density for the three classes. Nicastrin is shown in green, Aph-1 in orange, PS1 in cyan, and Pen-2 in yellow. α-Helical density that is unaccounted for by the γ-secretase model is shown in purple. The same color code is used throughout this paper. (B) Schematic representation of the γ-secretase atomic models. TMs of PS1 are numbered. The active site aspartates are shown in red. The purple dashed box highlights TM2 of PS1, which is only ordered in class 1. The purple arrows indicate the orientation of TM6, which is different in each class.
Figure 3—figure supplement 1. Fourier shell correlations for the three apo-state classes.
(A) FSC between the refined atomic models and the maps. (B) FSC between reconstructions from independently refined halves of the data sets.