Figure 2. Pathway and network representation of EGF signaling.
(A) In the simplified pathway representation, heterogeneous nodes and edges correspond to genes, proteins, small molecules, and their regulatory and catalytic relationships. Nodes do not interact directly but participate in reaction events designated by white squares. (B) In the network representation, all nodes correspond to the same type of biological entity (gene products). Edges derived from curated pathways are shown as bold arrows. Additional gene-gene interactions derived from gene co-expression and physical protein interactions are shown as light lines.