TABLE 4.
Magnitudes of avibactam %fT>CT associated with stasis and bacterial killing of P. aeruginosa in thighs of mice
| Strain | MIC (mg/liter) |
Ceftazidime dose (mg/kg) q2h | Avibactam %fT>CT 1b |
CAZ-AVI %f T>MICc | ||
|---|---|---|---|---|---|---|
| Ceftazidime | CAZ-AVIa | Stasis | 1-log kill | |||
| 1 | 128 | 8 | 32 | 37.2 | 65.7 | 34.6 |
| 5 | 128 | 8 | 64 | 14.1 | 32.9 | 49.3 |
| 7 | 64 | 4 | 64 | 50.4 | 65.3 | 63.5 |
| 11 | 128 | 16 | 64 | 29.1 | 37.5 | 34.6 |
| 18 | 32 | 2 | 64 | 24.2 | 33.2 | 77.5 |
| 19 | 64 | 4 | 32 | 62.5 | 67.2 | 49.3 |
| Mean | 31.0 | 46.9 | 51.9 | |||
| SD | 13.7 | 17.1 | 18.7 | |||
a
MIC of ceftazidime measured with a fixed avibactam concentration of 4 mg/liter.
b
Stasis, no growth of microorganisms compared to the initial inoculum; 1-log kill, 1-log10 kill of microorganisms compared to the initial inoculum; CT, threshold concentration (virtual in vivo inhibitory concentration) in mg/liter; %fT>CT 1, percentage of time that free concentrations of avibactam stay above a CT of 1 mg/liter.
c
Percentage of time that free concentrations of ceftazidime stay above the MIC of CAZ-AVI (the MIC of ceftazidime as determined in the presence of a fixed avibactam concentration of 4 mg/liter).