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Example of exposure response of avibactam in neutropenic thigh- and lung-infected mice treated with ceftazidime and various doses of avibactam q2h. CAZ, ceftazidime; AVI, avibactam; ΔlogCFU, change in log10 CFU compared to the initial inoculum. MIC of ceftazidime-avibactam versus this strain, 4 mg/liter.
