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. Author manuscript; available in PMC: 2016 Jan 5.
Published in final edited form as: ACS Chem Biol. 2015 Apr 17;10(7):1616–1623. doi: 10.1021/acschembio.5b00240

Figure 3. Correlation between relative fractional incorporation of isotopic glucose into complex lipid species and FASN inhibitor sensitivity reveals predictive biomarkers.

Figure 3

We show correlation plots between FASN inhibitor sensitivity and fractional isotopic incorporation of [13C]glucose into fully labeled complex lipids. We find that [13C] C16:0 LPA, C16:0/18:1 DAG, C16:0/18:1 PC, and C16:0 LPC (all m+19), but not other lipid species, strongly correlate with TVB-3567 sensitivity across the six cancer cell lines tested in Fig. 1 (Pearson correlation coefficients of r2>0.97). Data are presented as mean ± sem; n=4 per group.