FIGURE 1. Effects of Childhood emotional Neglect, Mineralocorticoid Genotype, and interaction of Mineralocorticoid Genotype and Childhood emotional Neglect on Threat-related Amygdala reactivitya.
a Panel A shows the left and right amygdala reactivity to the faces > shapes contrast (neurological format): right Montreal Neurological Institute (MNI) coordinates: x=18, y=−6, z=−18; 217 voxels; t=14.74, p<0.001, family-wise error-corrected; left MNI coordinates: x=−16, y=−6, z=−14; 146 voxels, t=10.62, p<0.001, family-wise error-corrected. Panel B shows that childhood emotional neglect is positively associated with amygdala reactivity. Panel C shows that val carriers have elevated threat-related amygdala reactivity relative to iso homozygotes. Panel D shows that childhood emotional neglect is positively associated with amygdala reactivity only in iso homozygotes. The model is plotted with raw data values, although statistics were run with mean-centered values. Highlighted areas indicate regions where the difference between the groups reaches significance. Importantly, removal of the outlier (−7 amygdala reactivity) does not change the results (overall model, F=3.40, df=5, 272, p=0.005; main effect of emotional neglect, p=0.004; main effect of val carrier status, p=0.07; interaction, p=0.04). Moreover, restricting analyses to individuals with a childhood emotional neglect score ≤15 (as no val carriers reported emotional neglect above a score of 15) produced the same pattern of results (overall model, F=3.48, df=5, 263, p=0.005; main effect of emotional neglect, p=0.02; main effect of val carrier status, p=0.03; interaction, p=0.02).