Table 1.
The top 10 “common” candidate genes downregulated or upregulated within PF-2341066–treated 3 KSHV+ PEL cell lines
| Gene symbol | Description | Fold change | ||
|---|---|---|---|---|
| BCP-1 | BC-1 | BCBL-1 | ||
| RRM2 | Ribonucleoside-diphosphate reductase subunit M2 | 0.38 | 0.41 | 0.21 |
| MUC1 | Mucin-1 | 0.53 | 0.26 | 0.32 |
| POLE2 | DNA polymerase ε subunit 2 | 0.39 | 0.47 | 0.26 |
| TMEM106C | Transmembrane protein 106C | 0.43 | 0.5 | 0.29 |
| FAM81A | Protein FAM81A | 0.46 | 0.5 | 0.3 |
| CHAC2 | Cation transport regulator-like protein 2 | 0.54 | 0.43 | 0.34 |
| TYMS | Thymidylate synthase | 0.42 | 0.52 | 0.39 |
| FBXO5 | F-box only protein 5 | 0.51 | 0.48 | 0.36 |
| ASPM | Abnormal spindle-like microcephaly-associated protein | 0.3 | 0.54 | 0.55 |
| DPAGT1 | UDP-N-acetylglucosamine–dolichyl-phosphate N-acetylglucosaminephosphotransferase | 0.52 | 0.54 | 0.33 |
| RN7SK | RNA, 7SK small nuclear transcript | 5.56 | 5.1 | 20.15 |
| HMGCS1 | Hydroxymethylglutaryl-CoA synthase, cytoplasmic | 8.11 | 4.03 | 4.03 |
| RNU1-4 | RNA, U1 small nuclear 4 transcript | 2.47 | 4.49 | 7.84 |
| RNVU1-18 | RNA, variant U1 small nuclear 18 transcript | 2.2 | 4.36 | 7.43 |
| SNORD3A | Small nucleolar RNA, C/D box 3A transcript | 3.01 | 5.24 | 3.98 |
| RNU1-1 | RNA, U1 small nuclear 1 transcript | 2.15 | 3.11 | 6.4 |
| MSMO1 | Methylsterol monooxygenase 1 | 5.42 | 2.23 | 2.13 |
| PPP1R15A | Protein phosphatase 1 regulatory subunit 15A | 1.86 | 3.58 | 4.05 |
| HMGCR | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 3.66 | 2.46 | 3.34 |
| PIK3IP1 | Phosphoinositide-3-kinase-interacting protein 1 | 3.31 | 3.07 | 3.03 |