Table 3.
Age-specific cumulative colorectal cancer risk percentages (95% confidence intervals) for African Americans with any mismatch repair (MMR) gene mutation or only MLH1 & MSH2 mutation carriers.
| Age (yrs) | Male | Female | ||||
|---|---|---|---|---|---|---|
| Gen Pop | All MMR mutation carriers | MLH1 and MSH2 mutation carriers | Gen Pop | All MMR mutation carriers | MLH1 and MSH2 mutation carriers | |
| 30 | 0.01 | 0.05 (0.01–0.21) | 0.09 (0.02–0.37) | 0.01 | 0.08 (0.02–0.33) | 0.14 (0.03–0.56) |
| 40 | 0.05 | 0.41 (0.10–1.66) | 0.71 (0.18–2.84) | 0.06 | 0.45 (0.11–1.81) | 0.77 (0.19–3.08) |
| 50 | 0.23 | 1.85 (0.46–7.31) | 3.17 (0.79–12.3) | 0.24 | 1.91 (0.47–7.54) | 3.27 (0.82–12.6) |
| 60 | 0.95 | 7.43 (1.88–26.9) | 12.5 (3.23–41.7) | 0.83 | 6.52 (1.65–23.9) | 11.0 (2.83–37.6) |
| 70 | 2.56 | 18.9 (5.02–57.3) | 30.3 (8.52–76.8) | 2.11 | 15.9 (4.16–50.5) | 25.8 (7.08–70.1) |
| 80 | 5.41 | 36.2 (10.5–83.9) | 53.9 (17.4–95.7) | 4.27 | 29.7 (8.31–76.1) | 45.6 (13.9–91.5) |
Gen Pop, general population