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. Author manuscript; available in PMC: 2015 Nov 14.
Published in final edited form as: Cell Rep. 2015 Oct 22;13(5):957–967. doi: 10.1016/j.celrep.2015.09.058

Figure 4. Injection of Leishmania alongside in vivo- or in vitro-isolated exosomes significantly enhances mice footpad lesions.

Figure 4

BALB/c mice were infected with 105 L. major metacyclics (META) or with 5 × 106 L. major stationary promastigotes (STAT) with or without 1 µg of midgut-isolated L. major exosomes (Gut) or 1 µg (A) and 10 µg (B) of in vitro-isolated L. major exosomes (Exo). (A, B) Lesions were monitored up to 10 weeks post-infection. (C–E) STAT and META groups from (B) on the 6th and 10th week post-infection, respectively. (C) Footpad images. (D) Lesion volumes. (E) Footpad parasite loads. Each data point represents the average + SEM of 6 to 8 mice per group and statistical significance at + p≤0.05, * p≤0.01, ** p≤0.001, *** p≤0.0001, ns, non-significant. FP, footpad. The results are representative of 1(A) or 2 (B–E) independent experiments.