Table 2.
Pan-Cancer CAGE Gene Ontology
| Top 25 GO Correlations |
|||
|---|---|---|---|
| # | Lowesta | Highesta | |
|
Down | |||
| Translation | 10 | −0.865 | −0.890 |
| Immune, T cell | 5 | −0.853 | −0.883 |
| Cancer-associated | 2 | −0.875 | −0.887 |
| Viral replication | 2 | −0.875 | −0.878 |
| IL-signaling | 2 | −0.869 | −0.874 |
| RNA processing | 1 | −0.886 | |
| Ago2-Dicer-silencing | 1 | −0.882 | |
| Protein metabolism | 1 | −0.879 | |
| Receptor processing | 1 | −0.869 | |
|
Up | |||
| Cancer-associated | 6 | −0.783 | −0.906 |
| Infection | 3 | −0.798 | −0.853 |
| HDAC | 3 | −0.795 | −0.852 |
| Platelet | 3 | −0.837 | −0.906 |
| Cytoskeleton | 2 | −0.801 | −0.886 |
| Hypoxia | 2 | −0.763 | −0.937 |
| Protease | 1 | −0.854 | |
| Immunodeficiency | 1 | −0.812 | |
| Differentiation | 1 | −0.810 | |
| Immune differentiation | 1 | −0.801 | |
| Methylation | 1 | −0.778 | |
| Metabolism | 1 | −0.768 | |
Top-ranking correlations of platelet-mRNA profiles with 3,875 Broad Institute curated gene sets. CAGE, Correlative Analysis of Gene Set Enrichment; GO, gene ontology; #, number of hits per annotation; IL, interleukin; HDAC, histone deacetylase.
a
Indicated are lowest and highest correlations per annotation.