Figure 5.
Representative Western blots and densitometric quantification of ICAM-1/β-actin (A), CK2/β-actin (B), and p-Nrf2/β-actin (C) in cytoplasmic cell lysate at 24 hours after intracerebral hemorrhage or sham surgery. Dimethyl fumarate (DMF) and control siRNA reduced ICAM-1 expression; TBCA and MAFG siRNA increased ICAM-1 expression (A). CK2 expression was increased in DMF treated, control and MAFG siRNA groups but reduced in vehicle and TBCA treated groups (B). p-Nrf2 expression was significantly reduced in vehicle treated group.(C). Data are expressed as mean ± SEM. N=6 per group. *p<0.05 compared to sham, #p<0.05 compared to Vehicle, @ p<0.05 compared to DMF 100mg, NS indicates no significant difference.