Figure 5.
Truncal location of driver aberrations and mutation spectrum in ten ccRCC tumors. (a) Percentage of cases in which a specific driver aberration was located on the trunk of the phylogenetic tree. n indicates the number of cases in which each event was found. Mut, mutation; methyl, methylation. (b,c) Mutation spectrum of nonsynonymous trunk versus branch mutations combined across all cases (b) and per case (c). The number of mutations analyzed is displayed on top of each bar. The difference between the spectra for trunk and branch mutations across all cases was assessed using a χ2 test. For specific mutation types, a Fisher’s exact test was used, and significant P values, corrected for multiple testing using the Benjamini-Hochberg method where appropriate (q values), are shown.