Figure 2.
Variant frequencies for the nonsynonymous somatic mutations in eight ccRCC tumors based on ultra-deep amplicon sequencing. Individual mutations are shown on the x axis, and variant frequencies are plotted on the y axis. Category 1 high-confidence driver mutations and category 2 probable driver mutations are labeled on the x axis and are highlighted by dashed boxes. Amplicon generation for deep sequencing failed for VHL mutations in EV005, EV006 and RMH002 and for a BAP1 mutation in RK26, and thus these could not be included. Mutations that define dominant (dom) and minority (min) clones in cases EV005, EV007, RMH008 and RK26 are indicated.