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. 2015 Nov 3;5:16109. doi: 10.1038/srep16109

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(A) NCI did not alter expression of β₂ARs in colon DRGs. (B) NCI markedly enhanced concentration of NE in blood plasma. *p < 0.05 vs. control (CON). (C) Application of NE (100 μg/1ml, i.p.) enhanced AWR scores in healthy rats. *p < 0.05 vs. baseline (Pre). (D) Time course of effect of NE at 100 μg/ml. Application of NE reduced distention threshold, starting at 0.5h and maintaining for at least 4h within our observation time period. *p < 0.05, compared with Pre.