Table 2. ASSESS and IGNITE trials.
| Parameter | ASSESS trial |
IGNITE trial |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall (n=1,162) |
Same method (n=254) |
Asian pacific patients (n=1,687) |
Russian patients (n=894) |
||||||||
| n/N (%) | 95% CI | n/N (%) | 95% CI | n/N (%) | 95% CI | n/N (%) | 95% CI | ||||
| Concordance | 1,035/1,162 (89.1) | 87.1-90.8 | 221/254 (87.0) | 82.2-90.9 | 1,310/1,687 (77.7) | 75.6-79.6 | 767/894 (85.8) | 83.3-88.0 | |||
| Sensitivity | 87/189 (46.0) | 38.8-53.4 | 25/56 (44.6) | 31.3-58.5 | 343/692 (49.6) | 45.8-53.4 | 33/109 (30.3) | 21.8-39.8 | |||
| Specificity | 948/973 (97.4) | 96.2-98.3 | 196/198 (99.0) | 96.4-99.9 | 967/995 (97.2) | 96.0-98.1 | 734/785 (93.5) | 91.5-95.1 | |||
| PPV | 87/112 (77.7) | 68.8-85.0 | 25/27 (92.6) | 75.7-99.1 | 343/371 (92.5) | 89.3-94.9 | 33/84 (39.3) | 28.8-50.5 | |||
| NPV | 948/1,050 (90.3) | 88.3-92.0 | 196/227 (86.3) | 81.2-90.5 | 967/1,316 (73.5) | 71.0-75.8 | 734/810 (90.6) | 88.4-92.5 | |||
n, numerator value for each parameter; N, denominator value for each parameter; PPV, positive predictive value; NPV, negative predictive value.