Table 1.
Biomarkers of pluripotency in mouse and human embryonic stem cells
| Biomarker | Role in mESC | Role in hESC |
| Oct4 | Pluripotency[200] | Pluripotency[4] |
| Sox2 | Pluripotency[215] | Pluripotency[4] |
| Nanog | Pluripotency[227] | Pluripotency[4] |
| Klf4 | Pluripotency[253,255] | Pluripotency[253] |
| c-Myc | Pluripotency[190] | Pluripotency[190] |
| SSEA1/CD15 | Pluripotency[18,19] | Not expressed |
| SSEA 3, 4 | Not expressed | Pluripotency[20,22] |
| TRA-1-68 | Not expressed | Pluripotency[24] |
| TRA-1-81 | Not expressed | Pluripotency[24] |
| Cripto-1 | Pluripotency[28,474] | Pluripotency[28,474] |
hESC: Human embryonic stem cell; mESCs: Mouse embryonic stem cells; SSEA: Stage specific embryonic antigens; TRA: Tumor rejection antigens.