Table 2.
Macrophage polarization and vascular inflammation
|
|
||
|---|---|---|
| M1 | M2 | |
| Atherosclerosis | Atherogenic | Atheroprotective and atherogenic |
| Endothelial activation Chemotaxis of inflammatory cells Weakening of cap Oxidative stress Prothrombotic activity Enlargement of necrotic core ? antigen presentation |
Uptake of oxidized lipoproteins Efferocytosis Production of IL-10 and TGF-β Promotion of neoangiogenesis |
|
|
| ||
| Vasculitis | Vasculitogenic | Vasculitogenic |
| Granuloma formation Giant cell formation Endothelial activation Oxidative stress Digestion of elastic tissues Media thinning Intimal hyperplasia ? antigen presentation |
Granuloma formation Giant cell formation Neoangiogenesis Intimal hyperplasia ? efferocytosis |
|