Table 3.
GPC classification using RIS + KET, LAM + KET, PLA + SAL and PLA + KET conditions, showing the effect of lamotrigine and risperidone pre-treatment on the ketamine-effected centrality
| Contrast | Accuracy (%) | p value | ||
|---|---|---|---|---|
| Placebo (pre-saline) | v | Risperidone | 75.00 | 0.007 |
| Saline | v | Ris + ketamine | 81.25 | 0.001* |
| Risperidone | v | Ris + ketamine | 62.5 | 0.17 |
| Ketamine | v | Ris + ketamine | 81.25 | 0.001* |
| Placebo (pre-saline) | v | Lamotrigine | 32.125 | 1 |
| Saline | v | Lam + ketamine | 93.75 | 0.001* |
| Lamotrigine | v | Lam + ketamine | 87.5 | 0.001* |
| Ketamine | v | Lam + ketamine | 43.75 | 0.872 |
| Lamotrigine | v | Risperidone | 62.5 | 0.154 |
| Lam + ketamine | v | Ris + ketamine | 93.75 | 0.001* |
Reported accuracies obtained with LOOCV and significance with (N = 1000) permutation testing
*Indicates a results passing Bonferroni correction