Table 4.
Concentration of transthyretin and its variants in 44 human plasma samples. Samples labeled with an “*” contain a +30Da point mutation.
| Sample | native TTR [mg/L] | Cysteinilation (Cys10) [mg/L] | Cys10Gly [mg/L] | Oxidation (Cys10) [mg/L] | Sulfonation (Cys10) [mg/L] | CysGly [mg/L] | Total TTR [mg/L] | ||
|---|---|---|---|---|---|---|---|---|---|
| 1 | 31.2 | 57.4 | 13.8 | 14.6 | 15.4 | 11.7 | 144.1 | ||
| 2 | 24.7 | 39.5 | 10.1 | 14.4 | 53.2 | 8.49 | 150.4 | ||
| 3 | 20.5 | 34.6 | 7.66 | 10.2 | 10.0 | 7.52 | 90.5 | ||
| 4 | 18.5 | 37.9 | 8.19 | 8.57 | 9.43 | 7.67 | 90.3 | ||
| 5 | 31.1 | 66.6 | 12.0 | 18.7 | 55.0 | 15.2 | 198.6 | ||
| 6 | 18.6 | 31.0 | 7.36 | 9.00 | 10.1 | 7.17 | 83.2 | ||
| 7 | 28.8 | 58.7 | 13.8 | 15.4 | 41.1 | 11.7 | 169.5 | ||
| 8 | 42.1 | 84.1 | 17.3 | 21.4 | 57.4 | 18.0 | 240.3 | ||
| 9 | 33.8 | 55.8 | 17.7 | 16.4 | 18.4 | 13.7 | 155.8 | ||
| 10 | 19.9 | 47.5 | 9.44 | 11.7 | 25.7 | 9.68 | 123.9 | ||
| 11 | 51.0 | 95.5 | 21.9 | 24.3 | 25.5 | 24.4 | 242.6 | ||
| 12 | 28.0 | 57.8 | 14.2 | 15.9 | 40.0 | 13.2 | 169.1 | ||
| 13 | 59.8 | 106.7 | 26.5 | 29.8 | 34.2 | 26.2 | 283.2 | ||
| 14 | 24.3 | 37.9 | 8.62 | 10.3 | 10.8 | 9.08 | 101.0 | ||
| 15 | 29.3 | 74.5 | 14.4 | 13.5 | 16.7 | 12.3 | 160.7 | ||
| 16 | 24.9 | 55.0 | 12.0 | 13.1 | 16.1 | 10.6 | 131.7 | ||
| 17 | 36.5 | 63.1 | 16.4 | 26.6 | 55.8 | 14.3 | 212.7 | ||
| 18 | 35.0 | 56.5 | 17.6 | 19.0 | 32.4 | 15.1 | 175.6 | ||
| 19 | 26.5 | 52.7 | 12.3 | 14.6 | 42.3 | 11.3 | 159.7 | ||
| 20 | 34.6 | 51.3 | 14.8 | 22.1 | 65.8 | 11.0 | 199.6 | ||
| 21 | 37.5 | 73.5 | 16.2 | 20.8 | 54.2 | 17.1 | 219.3 | ||
| 22 | 26.9 | 42.7 | 12.9 | 14.5 | 40.8 | 10.9 | 148.7 | ||
| 23 | 32.7 | 78.2 | 14.2 | 19.0 | 51.7 | 15.9 | 211.7 | ||
| 24 | 12.7 | 21.4 | 6.84 | 6.22 | 6.61 | 5.70 | 59.5 | ||
| 25 | 23.5 | 48.5 | 11.5 | 11.0 | 12.8 | 8.72 | 116.0 | ||
| 26 | 32.9 | 66.5 | 12.6 | 18.7 | 62.5 | 12.4 | 205.6 | ||
| 27 | 18.8 | 50.7 | 8.10 | 8.46 | 11.8 | 9.25 | 107.1 | ||
| 28 | 45.8 | 87.3 | 17.1 | 20.0 | 23.1 | 21.9 | 215.2 | ||
| 29 | 33.4 | 73.3 | 17.2 | 17.1 | 37.7 | 15.3 | 194.0 | ||
| 30 | 22.9 | 49.8 | 9.32 | 9.95 | 12.4 | 9.37 | 113.7 | ||
| 31 | 47.0 | 100 | 22.3 | 25.4 | 62.1 | 22.1 | 278.9 | ||
| 32 | 34.5 | 68.9 | 15.2 | 18.5 | 46.2 | 13.5 | 196.8 | ||
| 33 | 33.0 | 59.5 | 12.5 | 15.7 | 38.9 | 11.7 | 171.3 | ||
| 34 | 33.5 | 66.9 | 13.3 | 13.2 | 17.6 | 12.7 | 157.2 | ||
| 35 | 32.9 | 65.3 | 13.4 | 15.9 | 41.7 | 14.9 | 184.1 | ||
| 36 | 30.0 | 48.4 | 13.2 | 14.8 | 43.0 | 9.99 | 159.4 | ||
| 37 | 15.8 | 26.7 | 6.04 | 6.51 | 7.15 | 5.92 | 68.1 | ||
| 38 | 47.9 | 55.8 | 17.6 | 23.8 | 49.6 | 16.2 | 210.9 | ||
| 39 | 10.4 | 17.9 | 5.08 | 4.73 | 5.01 | 4.68 | 47.8 | ||
| 40 | 30.3 | 69.5 | 12.4 | 14.7 | 36.1 | 12.9 | 175.9 | ||
| 41 | 26.7 | 83.7 | 10.7 | 11.8 | 19.3 | 13.1 | 165.3 | ||
| Δ(+30Da) | Δ (+30Da) | ||||||||
| * 42 | 20.6 | 20.6 | 41.4 | 32.7 | 7.85 | 24.0 | 6.89 | - | 154.0 |
| * 43 | 19.7 | 20.5 | 42.1 | 32.4 | 8.32 | 26.6 | 8.69 | - | 158.3 |
| * 44 | 29.2 | 30.0 | 41.1 | 36.7 | 6.02 | 42.8 | 9.84 | - | 195.7 |