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CNPs induce vascular sprouting in CAM assay. Nanoparticle-induced angiogenesis measured by Chick CAM assay (A–D). The extent of angiogenesis on CAM’s treated with either (A) methylcellulose, (B) 50 ng of VEGF-A, (C) 1μg of CNP1 or (D) 1μg of CNP2. (E) The extent of CAM angiogenesis measured by counting the number of vascular sprouts from tertiary vessels in a minimum of 8 separate experiments. Hpf: high power field.
