Table 3.
Combination of the main SS-related immunological profiles (ANA/RF, Ro/La, and cryoglobulinemic-related markers) according to the presence or absence of serum HCV-IgG antibodies
| ANA/RF combination | Negative HCV-IgG | Positive HCV-IgG | Bilateral P value |
| N = 306 | N = 74 | ||
| ANA and RF | 94 (31 %) | 29 (39 %) | <0.001 |
| Isolated ANA | 200 (65 %) | 32 (43 %) | |
| Isolated RF | 12 (4 %) | 13 (18 %) | |
| Ro/La combination | Negative HCV-IgG | Positive HCV-IgG | Bilateral P value |
| N = 314 | N = 21 | ||
| Anti-Ro and anti-La antibodies | 178 (57 %) | 12 (57 %) | 0.014 |
| Isolated anti-Ro antibodies | 114 (36 %) | 4 (19 %) | |
| Isolated anti-La antibodies | 22 (7 %) | 5 (24 %) | |
| Cryoglobulinemic-related markers combination | Negative HCV-IgG | Positive HCV-IgG | Bilateral P value |
| N = 38 | N = 60 | ||
| Cryoglobulins+RF+low C4 | 7 (18 %) | 28 (47 %) | 0.019 |
| Cryoglobulins+RF | 12 (32 %) | 13 (22 %) | |
| Cryoglobulins+low C4 | 6 (16 %) | 10 (17 %) | |
| Isolated cryoglobulins | 13 (34 %) | 9 (15 %) |
SS Sjögren syndrome, ANA antinuclear antibodies, RF rheumatoid factor, HCV hepatitis C virus, IgG immunoglobulin G, C4 complement component 4