Skip to main content
. Author manuscript; available in PMC: 2016 Sep 3.
Published in final edited form as: Mol Cell. 2015 Jun 4;59(5):867–881. doi: 10.1016/j.molcel.2015.05.006

Figure 3. DDR-regulated ubiquitination of mitotic spindle proteins.

Figure 3

(A) Biological pathways and functions significantly enriched among proteins ubiquitinated in response to UV radiation in the UV, UV-MG132, or UV-SCX datasets. Analysis was performed with Ingenuity and significance determined using the right-tailed Fisher's exact test.

(B) Log2(L/H) ratios for diGly sites on centromere proteins (CENPs) deubiquitinated in response to UV and/or IR in the UV-SCX or IR-SCX datasets.

(C) Mitotic spindle proteins ubiquitinated or deubiquitinated in response to UV (rectangles), IR (ovals), or both (rectangular oval). Green proteins (Log2 ratios >1) are ubiquitinated and red proteins (Log2 ratios <−1) deubiquitinated. Data are from the UV, UV-MG132, UV-SCX, IR, IR-MG, or IR-SCX datasets.