Table 1.
Summary of diseased recipient mice transplanted with Kras; D3a−/− LSK or MP cells
| Donor cells (#/recipient) | Competitors (#/recipient) | Recipients (#) | Diseased animals (%) | Disease diagnosis(#) |
|---|---|---|---|---|
| LSK (1,000) | BM (200,000) | 3 | 100 | T-ALL and MPN (1) MPN(1) AML (1) |
| MP (15,000) | BM (200,000) | 7 | 86 | MPN (3) AML (1) |
LSK (Lin− Sca1+ cKit+) and MP (myeloid progenitor) cells were flow sorted from KrasG12D/+; Dnmt3a−/− bone marrow and transplanted with congenic competitor cells (BM: bone marrow) into lethally irradiated recipients. Mice were monitored closely until a moribund stage. Note: some animals died before we could catch and analyze them. T-ALL, acute T-cell lymphoblastic leukemia/lymphoma; MPN, myeloproliferative neoplasm; AML, acute myeloid leukemia.