Table 1.
Antibody and T cell responses to each peptide in the 6MHP vaccine.
| Epitope | Sequence | # of aa | Ab Responsea | T cell responseb |
|---|---|---|---|---|
| Tyrosinase386-406 | FLLHHAFVDSIFEQWLQRHRP | 21 | 78% | 32% |
| Melan-A/MART151-73 | RNGYRALMDKSLHVGTQCALTRR | 23 | 66% | 24% |
| gp10044-59 | WNRQLYPEWTEAQRLD | 16 | 41% | 5% |
| Tyrosinase56-70 | AQNILLSNAPLGPQFP | 15 | 6% | 5% |
| MAGE-A3281-295 | TSYVKVLHHMVKISG | 15 | 0% | 49% |
| MAGE-A1,2,3,6121-134 | LLKYRAREPVTKAE | 14 | 0% | 22% |
a
% of patients with Ab response to each peptide, n = 32
b
% of patients with T cell response to each peptide, as previously reported, n = 37 (31)