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. Author manuscript; available in PMC: 2016 Sep 1.
Published in final edited form as: Cell Rep. 2015 Aug 20;12(9):1430–1444. doi: 10.1016/j.celrep.2015.07.050

Figure 4. PS1KO lysosomes are markedly deficient in vATPase V0al subunit and vATPase activity.

Figure 4

(A) In highly enriched lysosomes from PS1KO cells, (B) V0al subunit levels were decreased (n=3), (C) ATP hydrolysis activity was reduced and (D) proton translocation ability of vATPase was decreased ConA treatment of WT cells for 24 hr prior to lysosomal enrichment decreased proton translocation, but had no effect in PS1KO cells* p<0.05, *** p<0.0001. Error bars: S.E.M