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. Author manuscript; available in PMC: 2016 Nov 1.
Published in final edited form as: Biomaterials. 2015 Aug 5;69:174–183. doi: 10.1016/j.biomaterials.2015.08.005

Figure 7.

Figure 7

Inhibition of integrins and downstream effectors influence differentiation. (a) Immunofluorescence image of MSCs stained with Runx2 and Osteopontin with or without inhibitors on 30 kPa substrates. Expression of early (Runx2) and late (Osteopontin) osteogenic markers for cells adherent to the star shape of fibronectin patterned substrates displaying how integrin α5β1 plays a critical role in osteogenic differentiation of MSCs. Scale bar is 40 μm. Error bars are standard deviations (N=3). (*P < 0.05, one-way ANOVA)