Table 1.
Body weights of CD, WD, and WDSp mice
| P Value | CD Group | WD Group |
WDSp Group |
|
|---|---|---|---|---|
| Sample size | 7 | 8 | 7 | |
| Pretreatment body weight, g | 0.09 | 12.0 ± 0.8 | 12.7 ± 0.4 | 14.0 ± 0.6 |
| Posttreatment body weight, g | 0.001 | 20.3 ± 0.5 | 28.0 ± 0.8* | 28.7 ± 2.0† |
| Change in body weight, g | 0.001 | 8.3 ± 0.4 | 15.3 ± 0.8* | 14.7 ± 1.7† |
| Tibia length, cm | 0.020 | 1.70 ± 0.00 | 1.73 ± 0.02 | 1.76 ± 0.02† |
| Retroperitoneal fat, mg | 0.001 | 76 ± 13 | 413 ± 38* | 353 ± 78† |
| Heart weight, mg | 0.007 | 81.8 ± 1.4 | 94.2 ± 2.1* | 92.7 ± 2.2† |
Values are means ± SE. Body weights of C57Bl6/J mice fed a Western diet (WD) high in fat and sugars for 4 mo compared with mice fed a control diet (CD) are shown. Although mice on the CD gained weight with age, WD caused an additional increment of body weight gain. Administration of spironolactone (Sp) had no effect on body weight under either dietary regime. WDSp, WD-fed mice that received Sp.
*
P < 0.05 for CD vs. WD groups;
†
P < 0.05 for CD vs. WDSp groups (post hoc comparisons).