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. 2015 Aug 26;35(9):1963–1974. doi: 10.1161/ATVBAHA.115.305896

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© 2015 The Authors.

Arteriosclerosis, Thrombosis, and Vascular Biology is published on behalf of the American Heart Association, Inc., by Wolters Kluwer. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.

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Figure 4. — Senescent vascular smooth muscle cells (VSMCs) induce chemotaxis, secrete active matrix metalloproteinase-9 (MMP-9), and upregulate inflammasome components. A, Number of THP-1 cells migrating toward control or senescent VSMCs, ±neutralizing interleukin-1α (IL-1α), MCP-1, or IL-8 antibodies. B, Enumeration of immune cells recruited to the peritoneum of mice in response to control or senescent VSMCs. C, Gelatin gel zymography showing level and activity of MMPs in the conditioned media of control, IL-1α–treated or senescent VSMCs. D, Amount of collagen produced by equal numbers of control or senescent VSMCs. E, Relative expression of transcripts for inflammasome-associated components in control or senescent VSMCs. Data represent mean±SEM of n=4 (A), 3 (B and D), 2 (E); *P≤0.05, **P≤0.02, ***P≤0.005. ND indicates not detected.