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The open field test. (a) Tracing of mouse movement during the 10-minute test period. (b) Percentage of time spent in the center area. (c) Number of entries into the center area. (d) Travelling speed. (e) Defecation number during the test. Data represent means ± SEM. * P < .05, socially isolated (SI) aged APP/PS1 mice (n=12) vs group (GR) controls (n=13).
