Table 3.
Loading Directionality and Brain Labels for the ICA Components Showing Ct/Sz Difference (Numbered in the Order of Decreasing Effect Sizes)
| Component Number | Effect Size (Partial Eta Squared) | Loadings Directionality | Brain Region Label (Positive/Negative) | L/R Volume (cm3) | Brodmann Area | L/R: Max Z Value (x, y, z) |
|---|---|---|---|---|---|---|
| 1 | 0.048 | Ct > Sz | Superior temporal gyrus | 10.4/9.2 | 13,22,38,41,42 | 9.3 (−42, 13, −11)/8.1 (46, 11, −7) |
| Inferior frontal gyrus | 5.4/4.7 | 13,45,47 | 9.1 (−40, 13, −14)/8.4 (42, 15, −13) | |||
| Insula | 5.8/5.4 | 13 | 8.6 (−44, 2, −5)/7.2 (46, 8, −4) | |||
| 2 | 0.033 | Ct > Sz | Superior frontal gyrus | 16.6/20.4 | 6,8,9,10,11 | 5.1 (−28, 52, 23)/5.7 (30, 52, 23) |
| Middle frontal gyrus | 14.5/17.7 | 6,8,9,10,46 | 5.1 (−28, 53, 19)/5.6 (30, 53, 19) | |||
| Medial frontal gyrus | 4.1/5.2 | 6,8,9,10,11 | 4.4 (0, 48, 20)/4.3 (4, 60, 3) | |||
| 3 | 0.027 | Sz > Ct | Brainstem | 3.3/2.2 | — | 7.1 (−8, −40, −25)/6.1 (0, −42, −30) |
| 4 | 0.009 | Ct > Sz | Fusiform gyrus | 3.3/4.4 | 18,19,37,20,36 | 6.8 (−20, −88, −16)/8.4 (20, −88, −14) |
| Cuneus | 0.8/2.6 | 17,18,19 | 5.2 (0, −93, 3)/6.9 (4, −93, 3) | |||
| Precuneus | 0.3/1.0 | 7,19 | 3.9 (−2, −78, 41)/5.9 (6, −81, 41) | |||
| 5 | 0.007 | Ct > Sz | Vermis | 13.6/16.1 | — | 7.9 (−2, −53, −2)/8.3 (2, −53, −2) |
| Declive | 11.5/11.9 | — | 6.7 (0, −65, −12)/6.7 (4, −65, −12) | |||
| 6 | 0.007 | Sz > Ct | Cerebellum | 7.2/7.1 | — | 6.4 (−30, −60, −42)/6.9 (28, −60, −39) |
| Inferior semilunar lobule | 7.8/8.6 | — | 7.1 (−26, −70, −40)/7.4 (28, −72, −40) | |||
| 7 | 0.006 | Ct > Sz | Inferior temporal gyrus | 2.9/3.1 | 20,37 | 11.2 (−57, −32, −22)/8.2(57, −28, −20) |
| Fusiform gyrus | 2.1/1.9 | 20,36,37 | 9.9 (−51, −25, −26)/10.1 (57, −32, −22) | |||
| 8 | 0.004 | Ct > Sz | Posterior insula | 4.7/4.8 | 13,47 | 9.1 (−36, −34, 18)/8.0 (36, −28, 20) |
| Superior temporal gyrus | 1.7/0.6 | 41,13,21,22,38 | 8.4 (−38, −36, 15)/5.3 (36, −32, 16) | |||
| Middle frontal gyrus | 2.4/2.3 | 6,8,10,11 | 7.6 (−30, 2, 44)/6.1 (28, 6, 44) | |||
| Hippocampus | 3.3/2.5 | 19,28,30,34,35,36,37 | 4.7 (−34, −17, −21)/4.2 (34, −15, −23) | |||
| Precentral gyrus | 1.5/0.8 | 6,9 | 13.2 (−34, 5, 29)/9.6 (36, 3, 29) | |||
| Inferior frontal gyrus | 2.0/1.2 | 9,47 | 11.3 (−38, 5, 29)/11.2 (36, 7, 29) | |||
| 9 | 0.004 | Ct > Sz | Inferior semilunar lobule | 1.0/1.8 | — | 15.3 (−4, −58, −42)/15.6 (4, −58, −42) |
| Cerebellar tonsil | 2.2/2.2 | 11.5 (0, −50, −38)/10.0 (4, −51, −40) |
Note: Negative component regions in bold italic. Ct, control; ICA, independent component analysis; Sz, schizophrenia.