Table II.
Grade 2 and Higher Toxicities Possibly, Probably, or Likely Related to Protocol Therapy
| Maximum grade of toxicity (total number of patient cycles =48) |
||
|---|---|---|
| Toxicity Type | Grade 2 | Grade 3 |
| Hematologic | ||
| Lymphocyte count decreased | 1 | |
| Neutrophil count decreased | 2 | |
| Platelet count decreased | 1 | |
| Constitutional | ||
| Fatigue | 1 | |
| Dermatologic | ||
| Palmar-plantar erythrodysesthesia | 1 | |
| Rash maculo-papular | 2 | |
| Gastrointestinal | ||
| Anorexia | 1 | |
| Metabolic/laboratory | ||
| Alkaline phosphatase increased | 2 | |
| Blood bilirubin increased | 1 | |
| Hypoalbuminemia | 1 | |
| Hypocalcemia | 1 | |
| Hypokalemia | 1 | |
| Hypophosphatemia | 1 | |
| Musculoskeletal /connective tissue | ||
| Other, not specified | 1 | |
| Pain | ||
| Abdominal pain | 1 | |
| Back pain | 1 | |
| Neck pain | 1 | |
| Pain in extremity | 1 | |
| Pain (not specified) | 1 | |
| Renal and Urinary | ||
| Proteinuria | 1 | |
| Respiratory | ||
| Dyspnea | 1 | 1 |
| Pleural effusion | 1 | |
| Upper respiratory infection | 1 | |