Table 2.
Most promising immunogens for an A. baumannii vaccine
| Locus tag | Mw | Pi | Product and Antigenicity scorea | Ref. |
|---|---|---|---|---|
| Cell wall/membrane/envelope biogenesis | ||||
| ABAYE0130 | 27.6 | 4.75 | Putative exported protein (OmpK), 0.73 | 38 |
| ABAYE1048 | 29.6 | 9.84 | Lipoprotein nlpD precursor, 0.64 | 39 |
| ABAYE1583 | 93.8 | 5.26 | Outer membrane protein/protective antigen OMA87, 0.63 | 40,41 |
| ABAYE2931 | 22.5 | 9.30 | Outer membrane protein/peptidoglycan-associated (lipo)protein, 064 | 42 |
| ABAYE3514 | 50.3 | 8.98 | type I secretion outer membrane, TolC family protein, 0.63 | 43 |
| Posttranslational modification, protein turnover, chaperones | ||||
| ABAYE3820 | 25.6 | 8.59 | FKBP-type 22kD peptidyl-prolyl cis-trans isomerase (FKlB), 0.66 | 44 |
| ABAYE2564 | 20.8 | 9.03 | alkyl hydroperoxide reductase subunit C22, 0.56 | 45 |
| ABAYE1454 | 18.5 | 5.38 | Cyclophilin, 0.48 | 46,47 |
| ABAYE0619 | 24.2 | 5.16 | ahpC/TSA family protein, peroxidase, 0.54 | 48,49 |
| Lipid transport and metabolism | ||||
| ABAYE0711 | 50.6 | 5.12 | putative long-chain fatty acid transport protein (Ompp1), 0.65 | 50,51 |
| Energy production and conversion | ||||
| ABAYE0776 | 67.0 | 5.94 | succinate dehydrogenase flavoprotein subunit, 0.54 | 52 |
| ABAYE0782 | 51.0 | 5.89 | dihydrolipoamide dehydrogenase (Lpd), 0.49 | 53 |
| Nucleotide transport and metabolism | ||||
| ABAYE3267 | 15.5 | 5.53 | Nucleoside diphosphate kinase (NDK), 0.37 | 54-56 |
aAntigenicity scores were done by VaxiJen v2.0 server.