Table 1. Comparing OIDD phenotypic module hit rates obtained by screening NPC and OIDD compound collections.
| Module | NPC hit rate a | OIDD hit rate b |
|---|---|---|
| Angiogenesis | 3.7% (92) | 5.1% (866) |
| Wnt potentiation | 2.4% (61) | 1.7% (296) |
| Insulin secretion | 0.6% (15) | 0.3% (46) |
| GLP-1 secretion | 0.7% (17) | 0.4% (71) |
| KRAS | 1.4% (35) | 1.0% (174) |
a the hit rate is the percent of 2,509 compounds screened having IC50 ≤ 5 μM in the primary concentration-response assays and meeting the selectivity criteria described in methods (e.g. reduction in tube area without cytotoxicity in the angiogenesis module).
b hit rate from screening 17,031 OIDD compounds as described in ref [10].