Figure 3. mCH is prevalent in human tissues.
a, The fraction of methylated cytosines in the CH context by sample. b-d, Representative mCH motifs from embryonic, (H1; b), tissue (LI-11; c), and brain (NRN; d) samples. The height of each letter represents its information content. e, A heatmap of genic mCAS patterns normalized to the flanking region. Each gene was assigned to one of twenty clusters, which is indicated by the number and tick marks on the y-axis. The tick marks on the x-axis indicate the upstream, transcription start, transcription end, and downstream segments of each gene. The boxes around various patterns highlight regions referenced in the main text. f, Bar plot of the ratio of the genome-wide mCAC to mCAG in various samples.