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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Trends Immunol. 2015 Jun 10;36(7):428–435. doi: 10.1016/j.it.2015.05.003

Figure 1. Variegation of TRM phenotypes in different tissue sites.

Figure 1

Expression of the TRM markers CD69 and CD103 on CD4+ and CD8+ TEM populations in tissue sites (indicated on horizontal axis) is depicted by proportion CD69+ based on position on the vertical axis, and proportion CD103+, indicated by colored shading of each cell type (ranging from yellow=0% to deep red/brown=100%). CD69 is absent on circulating cells and is progressively upregulated on TEM with the highest expression levels seen in mucosal sites. CD103 expression is highest in CD8+ TEM in mucosal tissue sites and mucosal-draining LN with variable expression by CD8+TEM in other tissues, and CD4+ TEM exhibit low or negligible CD103 expression.