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LDH release of HepG2 cells within two weeks in the different culture models. Data are shown as mean ± SD (n = 3). Significant differences (p < 0.05) are indicated as follows: * 2D vs. chip culture at the respective day, # within 2D culture vs. day 1, 2, 3, 6, and 9, $within chip culture vs. day 1 and 3, and & within static 3D culture vs. day 1, 2, 3, and 6.
