Fig. 2.
Myeloid lineage knockout of Adam10 reduces lethality from S. aureus pneumonia. a Survival of control and Adam10−/− mice following intranasal infection with 2-3 × 108 CFU S. aureus USA300/LAC, scored over 5 days. One representative experiment of 6 using 7-13 mice per group is shown. * p = 0.01, Gehan-Breslow-Wilcoxon test. b BAL fluid protein concentration in mice infected as in a, harvested for analysis 24 h after infection. c S. aureus recovery from left lung tissue harvested 24 h after infection and homogenized for bacterial CFU quantification. d Lung histopathology in control and Adam10−/− mice infected as in a, harvested 24 h after infection and stained with HE. Black scale bar (low magnification images) = 1 mm; yellow scale bar (high magnification images) = 50 μm.