. Author manuscript; available in PMC: 2016 Mar 1.

Published in final edited form as: Ann Neurol. 2015 Mar;77(3):469–477. doi: 10.1002/ana.24337

Table 3.

Association of rs7759295 with cognitive and pathological phenotypes in ROS and MAP.

Phenotype	Analysis	Sample Size	rs7759295 p-value	rs7759295 effect size
Neuritic Plaques	linear regression	1001	0.0082^*	0.1^†
Aβ Density	linear regression	984	0.19	0.11^†
Diffuse Plaques	linear regression	1001	0.015	0.085^†
Tau Tangle Density	linear regression	976	0.00049^**	0.33^†
Neurofibrillary Tangles	linear regression	1001	0.0091^*	0.076^†
Global Cognition	general linear mixed model	3421	0.0023^*	−0.012^†

^**

This association surpasses the locus-wide significance threshold of p<1.4×10⁻³.

This association surpasses the secondary association significance threshold of p<0.01.

^†

The reported effect size is the regression coefficient, β, of rs7759295^C.